CBD can reduce or increase the effects of certain prescribed medications by interacting with receptors throughout the body’s Endocannabinoid System (ECS) and by inhibiting the activity of cytochrome P450. Due to the nature of chemical compounds, virtually every substance, including CBD, will interact with other substances.
For example, several studies have shown that treatment with CBD improved quality of life and sleep quality for people with Parkinson’s disease . A study of 16 people undergoing chemotherapy found that a one-to-one combination of CBD and THC administered via mouth spray reduced chemotherapy-related nausea and vomiting better than standard treatment alone .
At the national level, any product of marijuana — including CBD — is still technically illegal when used medically. Although the CBD hemp oil benefits 2018 Farm Bill legalized the production of hemp nationally, that’s only permitted if it’s not marketed for medical use or as a dietary supplement. CBD products intended for medical use should undergo an FDA review process. This is very important for cancer patients to understand, as many people think CBD oil is not a medicine. They think of it more as a vitamin or a supplement, so they might not let their doctors know they’re using it.
In the United States, the cannabidiol drug Epidiolex was approved by the Food and Drug Administration in 2018 for the treatment of two epilepsy disorders. Since cannabis is a Schedule I controlled substance in the United States, other CBD formulations remain illegal to prescribe for medical use or to use as an ingredient in foods or dietary supplements. In 2016, investigators tested 84 CBD products and found that only 31% were labeled correctly.
Similar to energy drinks and protein bars which may contain vitamin or herbal additives, food and beverage items can be infused with CBD as an alternative means of ingesting the substance. In the United States, numerous products are marketed as containing CBD, but in reality contain little or none. Some companies marketing CBD-infused food products with claims that are similar to the effects of prescription drugs have received warning letters from the Food and Drug Administration for making unsubstantiated health claims. In February 2019, the New York City Department of Health announced plans to fine restaurants that sell food or drinks containing CBD, beginning in October 2019.
For other liver related conditions, however, cannabis use may have more complicated interactions. Chronic hepatitis C virus, for example, may be worsened by cannabis use. Animal studies show cannabis can actually worsen liver fibrosis and steatosis in hepatitis C.
examining the effects of cannabidiol delivered through an inhaler on cigarette consumption among smokers wishing to quit smoking, suggests a 40% smoking reduction in the treatment group compared to placebo . A study done on 4657 adult Americans from the National Health and Nutrition Examination Survey showed that marijuana use was associated with lower levels of fasting insulin and HOMA-IR, and smaller waist circumference .